Arturo Pérez Del Castillo was born in Concepcion, Chile. He started working for an advertising agency, but eventually joined his brother Jorge Perez del Castillo in Buenos Aires, Argentina, in 1948. He got a job as a letterer and illustrator with Editorial Columba and its magazine Aventuras, and remained affiliated with the publisher until the mid 1950s. He did his first work for for the comic weekly Aventuras, and a year later, he also created comic strips for the magazines Intervalo and El Tony. He quickly became famous for his skillful and detailed penwork, mainly for western comics.
Del Castillo's most famous work is the Hector Oesterheld scripted 'Randall: the Killer' series, that commenced publication in Hora Cero in 1957. Del Castillo refined his graphic style even further and other important works followed. He joined the Italian agency of Rinaldo Dami and from the late 1950s throughout the 1960s. He mainly worked for the British publisher Fleetway, starting with a number of comic strip adaptations of Alexandre Dumas novels, including 'The Three Musketeers' and 'The Man in the Iron Mask'.