After taking part in a contest at Angoulême and studying Alpha Arts, Isa sent the first pages of her series 'Puddingham Palace' to Spirou. She was accepted, and from 1997 this series, about a crazy royal family and its animal servants, is published in Spirou. The series was published in albums by Dupuis from 2001 and 2004. She subsequently began 'Agent Kärchou', a series about a dog detective published in L'Écho des Savanes and by Albin Michel.