As a child he liked to draw, and after discovering his first Steve Ditko “Spider-Man” comic, he began creating his own comic books.
While majoring in philosophy and psychology at The Ohio State University, Hornschemeier was introduced to the graphic novel Ghost World by Daniel Clowes and began exploring underground and literary comics. He saw that comics could be a venue for exploring issues from his studies and other interests, and within a year he began publishing his own black and white comics under the banner "Sequential,” a series of work which has since been compiled by AdHouse Books as “The Collected Sequential.”
From 2002 to 2007, Hornschemeier also sang and played guitar for the (now defunct) band Arks. Since 2008 he has periodically released music under the name Music Hall.