Lorenzo Mattotti (born 24 January 1954) is an Italian comics artist as well as an illustrator. His illustrations have been published in magazines such as Cosmopolitan, Vogue, The New Yorker, Le Monde and Vanity Fair. In comics, Mattotti won an Eisner Award in 2003 for his Dr Jekyll & Mr Hyde graphic novel.
Mattotti was born in Brescia (Lombardy).
He studied architecture when he was young, but did not finish the course. Instead he became a comics artist. After a few traditional comic stories he decided he wanted to tell different kinds of stories and portray these in a different style.
Il Signor Spartaco was the first comic made under this ambition. The story centred on the dreams of a train passenger making it possible for Mattotti to use forms and colors in a way previously unseen in the classic French-Belgian comic world. He focused more on the inner world of his characters and the total absence of an adventure was also a radical change in the comics universe.