Bruno Di Sano was born in Saint-Nicolas, in the region of Liège.
He published his first comic pages in 1971 in Aredit, called 'Waterloo'. Two years later, he had a short story published in Thierry Groensteen's fanzine Buck. He soon was present in the magazine Renault Contact, the fanzine A Propos De and in Spirou. He began illustrating games at A.L.I, which he did for ten years. From 1979, Di Sano cooperated with Hachel on 120 strips of 'Puppy', and he created a couple of pages for Bi-Fi.
'L'Île de Cassiopée' was his first album, that appeared at Deligne in 1981. He continued working for his publisher by succeeding Jacques Géron on the series 'Les Conquistadors de la Liberté'. He made his debut in Tintin in 1984 with the series 'Arnold Le Rêveur' (text by Thaulez and Dufaux) and 'Le Jeune Renaudin' (text by Dufaux and later Mythic).
In 1988, he took over the characters 'Platon, Torloche et Coquinette' from Renaud in Hello Bédé (text by Didgé). At the same time, he assisted Dupa on 'Cubitus'.
In 2001, Di Sano teamed up with Walthéry and Mythic, to work on the erotic strip 'Une Femme dans la Peau', which was later retitled to 'Johanna'. He also worked with Walthéry on an album of 'Natacha' in 2007.