Bruno Bazile was born in Saint-Nazare. He developed an early interest in comics and enrolled at the Faculty to Plastic Arts in Rennes. He was an apprentice at Jean-Claude Fournier's atelier, and drew for children's publications like Mikado and Fripounet between 1985 and 1992. He teamed up with Michel Plessix to create 'Les Forell', a series of which two books were published by Dargaud in 1997 and 1998. Bazile turned to a semi-realistic style for his book 'Les Faussaires', which he wrote and drew for Hors Collection in 2001.
He returned to humor with the parody series on British culture called 'Les Avatars', together with writer Pierre Veys (Dargaud, 2002-2004). Bazile and Veys continued their collaboration with 'Arthur et Merlin' (Soleil, 2004-2005). Bazile was additionally the artist of the political parody 'Les Aventures de Sarkozix', which is written by Wilfrid Lupano and Guy Delcourt since 2010.