1968-12 Colan/Palmer: Doctor Strange #175 p05

"over the past couple of issues, Gene had slowly moved away from the rectangular panels that were then comics’ usual fare. [...] In some ways, this approach may have been the early honing of a double-edged sword, because I’ve long wondered if the increasingly irregular panel shapes didn’t confuse some of the younger readers we needed to support the book...but, at that time, influenced by fan reaction to Steranko’s work, Stan was encouraging artists and writers to be experimental, to try daring new ways of telling a story...and this was Colan’s."
--Roy Thomas : Doctor Strange Masterworks Vol. 03 p07