After studying art in Gloucester, Frank Humphris worked as a painter and illustrator for a while. During World War II, he was a cartographer at the War Office. In 1952 Humphris took over the graphic duties of the 'Riders of the Range' series from Jack Daniel and Angus Scott. This western series was a comic adaptation of a radio play from the late 1940s and appeared in Eagle magazine. Humphris drew the series until 1962.