Enric Sió i Guardiola settled in Paris, France, in 1977, where he participated in the collection 'L'Histoire de France en Bandes Dessinées' by Larousse. He contributed to many of the important and alternative European comic magazines of the time, such as Charlie Hebdo, Fluide Glacial and Pilote, and also to the Spanish magazines Totém and Rambla after his return to his home country in 1979.
From the 1980s, he focused more and more on commercial illustration, photography and film. In 1985, he did launch and edit the short-lived adult comic magazine La Oca, that ran the work of some of his favorite artists, such as Guido Crepax, Dino Battaglia and Sergio Toppi. His photobook 'Barcelona, Guapa!', containing nudes on popular spots in Barcelona, was released in 1992.
His last work was a caricature of Pinochet that was published in the newspaper Avui on 31 October 1998, the day he suffered a fatal stroke. Enric Sió is considered one of the innovators of Spanish comics, together with his contemporaries Josep María Beá, Luis García, Felipe Hernández Cava, Carlos Giménez, Fernando Fernández and Adolfo Usero.