Willem Vleeschouwer was born in Hilversum and attended the Graphic Art School in Utrecht and the Rietveld Academy in Amsterdam. Early in his career, he made illustrations for Anti Apartheids Nieuws, and for a punk card game for music magazine Oor. His first comic was 'De Wonderbaarlijke Reis van Jacobus Maneschijn en Sientje Zeester', a story written by Willem Wilmink, and published daily newspaper in De Waarheid in 1978.
It was followed by two stories of 'Duppie' with Gerard van Santen ('Duppie en de ZZ-sekte', 'Duppie en het Doorbroken Isolement') and the series 'Flip Vla en Pintie Prima', both for Oor. Vleeschouwer was one of the artists published by Ger van Wulften's publishing house Espee in the late 1970s and early 1980s.
Vleeschouwer's best known comics are his 'Spoorstraat' stories 'De Wraak van de Dikke Ong' (1996), 'Stront aan de Knikker' (2001) and 'De geheime spleet' (2009), that are all published by Oog & Blik. His cartoons and illustrations have graced the pages of magazines like Elsevier, Esquire, PSV-Voetbalblad, Autoweek, Het Parool, Hard Gras and Cosmopolitan.