Sergio Aragonés Domenech was born in San Mateo, Spain, but moved to France and eventually Mexico, because of the Civil War. He grew up in Mexico City, producing streams of cartoons for his friends. In 1953, one of these friends sent some to the Mexican humor magazine Ja Ja, which printed them. He also began a collaboration with the magazine Mañana.
He studied architecture for a while, and worked as a clown and pantomime artist, which he learned under the guidance of Alejandro Jodorowsky. Aragonés headed for the USA in 1962, where he began his longtime collaboration with MAD magazine. Aragonés became known for his section 'A Mad Look At....' and his many pantomime comic strips, called marginals, which were inserted into the margins and between panels of the magazine. Aragonés has contributed to nearly every issue of MAD since 1963.
In the late sixties, Aragonés began a collaboration with DC Comics, drawing for titles like 'Angel and the Ape', 'Inferior Five', 'Young Romance' and 'Jerry Lewis', as well as some horror anthologies. He also served as a plotter for other artists and co-created serials like the western 'Bat Lash' and the humor title 'Plop!' (1973-1976).
He started his classic fantasy parody 'Groo the Wanderer' with scripts by Marc Evanier in the alternative comic book Destroyer Duck in 1982.