Born in Milan, Sandro Angiolini began his comics career in the 1940s, drawing cartoons and illustrations for some newspapers and magazines.
He also took part in the creation of the animated film 'La Rosa di Bagdad', and drew comics for magazines like Incanto, Luna Park and Festival. In the 1950s, Angiolini began a long collaboration with the publisher Dardo, drawing 'Chicchirichi' and other series for children, but also episodes of 'Capitan Miki', 'Il Grande Blek' and 'Jim Toro'.
In December 1966 he was the first to illustrate one of Italy's most important sexy comics, 'Isabella', written by Renzo Barbieri and Giorgio Cavedon. Later on he drew the adventures of the secret agent 'Goldrake'. He switched publishers in 1968 and joined Furio Viano, where he created 'Vartan', 'Una', 'Belzeba' and 'La Poliziotta'.