Miguelanxo Prado, born in La Coruña, studied architecture, while he published his first work in the fanzine Xofre. In the 1980s, he contributed to magazines like Creepy ('Mar de Tinieblas'), Comix Internacional ('Fragmentos de la Enciclopedia Delfica'), Zona 84 ('Stratos'), El Jueves, Cairo and Cimoc. Book collections of his work were published in Spain by Norma Editorial, and by Casterman and Les Humanoïdes Associés in France. For Les Humanoïdes, he made such books as 'Chienne de Vie' (1988), 'C'est du Sport' (1989) and 'Y'a Plus de Justice' (1991). He also produced erotic stories, which appeared in L'Echo des Savannes.
With Fernando Luna, he created the police parody 'Manuel Montano' in Cairo in 1987-88. His best-known book is 'Trazo de Tiza/Trait de craie ' (1992).
In 1995, following a trip through Portugal with writer Éric Sarner, he illustrated 'Une Lettre Trouvée à Lisbonne' in the collection Voyage sans Amarres of D.S. publishers. In the following year, he made an adaptation of 'Peter and the Wolf' and Laura Esquivel's novel 'La Ley del Armor'. He created 'Quotidiana Delirante' for Norma in 1997.
His short stories for Chienne de Vie and C'est Du Sport were collected in the series 'Chroniques Absurdes' in the collection Expresso by Dupuis in 2004 and 2005. In 2003, Prado worked with Neil Gaiman on 'Thee Sandman: Endless Nights - Dream: The Heart of a Star'.