Michel Rodrigue was born in Lyon in 1961. He attended the National School of Fine Arts, and also studied midieval archeology. Between 1983 and 1985 he was part of the French rugby team, and in 1987, he designed the official French mascot for the world rugby championship. He made his comics debut with the rugby strip 'Mézydugnac' in Midi Olympique in 1984.
Two years later, he published of his comic book adaptation of Edmond Rostand's 'Cyrano de Bergerac' with Lionel Garcia and Jean-Claude Vruble at Vents d'Ouest. With Vruble he also worked on the fourth book of 'La Révolution Française', scripted by Patrick Cothias and published by Vents d'Ouest. He also participated in other books by this publisher. In 1987 he worked with Roger Brunel on another rugby comic, 'Rugby en B.D.', published by Glénat. In the same register, Rodrigue and Brunel then created 'Du Monde dans la Coupe!', 'Concept', 'Le Rugby en Coupe' and 'La Foot par la Bande', published by Glénat and Hors Collection.
In 1999 and 2000 he created three albums in the comical series 'Doggyguard' with Bob de Groot for Lombard. For this same publisher, he took over the artwork of the detective series 'Clifton' (originally created by Raymond Macherot) in 2003.