Malo Kerfriden was born in the Breton town of Redon. His grandfather was the writer Pierre-Jackez Hélias and his father was an editor of the Breton comics fanzine Frilouz. He studied Literature and Plastic Arts in Rennes and during this period he contributed to the Rennes-based fanzine Atchoum alongside authors like Pascal Bertho, David Chauvel, Jérôme Lereculey, Fred Simon and Joub.
By 1994 he joined the Fine Arts atelier in Angoulême where he stayed for three years, while also playing and recording with the band The Lost Minds. He returned to Rennes in 1997, where he started the Twin Peaks atelier with Lionel Chouin and Marc-Antoine Boidin, two of his former Angoulême colleagues. Hervé Boivin and Isabelle Cochet also joined the studios. He started the 'Quarterback' series with writer David Chauvel in 2000. It was published by Delcourt until 2003. His next series was the fantasy comic 'KGB' with scriptwriter Valérie Mangin for Éditions Quadrants from 2006 to 2010.
Kerfriden made the first book in the thriller series 'Traffic' with Alexis Robin for Bamboo in 2009 and started the horror series 'La Rage' with Pierre Boisserie for 12bis in 2011 as well as 'Otaka Bleu' with Richard Marazano for Dargaud in 2012.