Cheung worked on several Marvel series during the mid- to late 1990s. He also worked on Scion for Crossgen Comics in the early 2000s. He later returned to Marvel, where he illustrated the five-issue New Avengers: Illuminati mini-series for Marvel Comics, and then pencilled two more issues of New Avengers.
He was named in August 2005 as one of Marvel's "Young Guns", a group of artists that, according to Marvel Editor-in-Chief Joe Quesada, have the qualities that make "a future superstar penciller". Other "Young Guns" include Olivier Coipel, David Finch, Trevor Hairsine, Adi Granov and Steve McNiven.
Cheung illustrated the 2010-2012 miniseries Avengers: The Children's Crusade.
In 2015, Marvel enlisted Cheung to create an Agents of S.H.I.E.L.D. poster for a panel devoted to that TV series at that year's San Diego Comic-Con