Ponzio began an additional career as an illustrator in 2000, starting with books covers for Éditions J'Ai Lu. He made his comics debut in 2004, when his futuristic comic 'T'ien Keou' was published by Soleil (script by Laurent Genefort). He wrote the script for his next book, 'Kybrilon', himself. It was published by Soleil in 2005. He continued with the diptych 'Dernier Exil' and the adaptation of the Barbet Schroeder film 'Inju' for Éditions Carabas in 2007 and 2008.
He has worked with scriptwriter Richard Marazano on the SF series 'Genetiks™' (Futuropolis, 2007-2010), 'Le Complexe du chimpanzé' (Dargaud, 2007-2008) and 'Le Protocole Pélican' (Dargaud, since 2011). For Vents d'Ouest, he drew the social chronicle 'Plus Belle Le Vie' from scripts by Janhel in 2009 and 2011. He succeeded Paul Gillon as the artist of Richard Malka's political thriller 'L'Ordre de Cicéron' at Glénat in 2012.