Chiang broke into comics in the mid-1970s, freelancing for Marvel Comics. Her career really took off in 1981, and throughout the 1980s and up until the mid-1990s she kept extremely busy, often lettering up to ten books a month. Titles Chiang has been particularly associated with include Transformers, Visionaries, Rom, Conan the Barbarian (1982–1990), Alpha Flight (1987–1994), Iron Man (1987–1990), Ghost Rider vol. 2 (1990–1996), What If? (1990–1995), and Impulse (1999–2002). Since the late 1990s her credits have not been as frequent, but she has maintained a steady output. Chiang's manga lettering work on series CHIKYU MISAKI and EMMA were both honored by being chosen as book of the month by NewType magazine which reviewed new anime and manga releases.
Presently, Chiang is working with Stan Lee's POW!Entertainment, Storm King Comics John Carpenter's ASYLUM, John Carpenter's Tales For A HalloweeNight V1 and V2, and John Carpenter's Tales of Science Fiction VAULT series, DC Entertainment in the comic branch lettering DC SUPER HERO GIRLS graphic novels and digital stories, Pete Ford of Resolution Independent, and various independent projects.