Gene Fawcette worked through the Eisner/Iger Studio in the early 1940s. His early work includes features like 'Fero', 'Buzz Crandall', 'Captain Wings', 'Wing Tips', as well as covers, support art and model pages for Fiction House. Then in the second half of the 1940s and in the 1950s, he was working on several features for Better Publications, like 'Princess Pantha', 'Out of the Shadows', 'Dennis the Menace', 'Adventures into Darkness', 'Supermouse' and 'Tara'. He was also present at Avon Comics with western, horror and science fiction stories and covers.
Fawcette additionally drew 'Sally O'Neil' for Quality Comics (1945-47) and horror stories for Toby Press, Marvel and Ziff-Davis (1950s). He then became a magazine artist, among others for Famous Fantastic Mysteries and Amazing Stories. He was managing editor and artist for the Picture World Encyclopedia between 1959 and 1961. By 1961 he became the artist of the Sunday feature and later also of the daily version of 'Our New Age', a newspaper comic on science and technology by Dr. Athelstan Spilhaus. The strip was previously drawn by Earl Cros and C.B. Felton, but it was Fawcette who drew it until the end in 1975. In the late 1970s he returned to comic books and drew covers with Warner Bros characters for Western Publishing, as well as Flash Gordon' and 'Tweety and Silvester' stories.