Fred Neidhardt made his debut in the magazine Spirou in 1996, illustrating a summary. He wrote the adventures of 'Monsieur Tue-Tout', illustrated by his brother Stéphane Neidhardt, for Psikopat between 1989 and 1991. The character reappeared in Fabrice Tarrin's debut album 'Les Aventures de Monsieur Tue-tout', which was also written by Neidhardt, at Soleil Productions in 1997. From 2000, he drew the gag strip 'Placide et Hutch' in Spirou. With Tarrin, he also co-wrote 'Nestor et Polux' for O'Groj, which appeared in the relaunched Pif Gadget. A first album appeared in November 2005. He also continued to write for his brother, which resulted in the title strip of the girl's magazine Manon in 2003. He writes and draws for L'Écho des Savanes since 2005, creating 2 page gag stories with 'Radin-Man'.