Federico Bertolucci enrolled at the Academy of Fine Arts in Carrara in 1998. That same year, he was hired by Disney Italia as an artist for their magazines Topolino and Minnie. In 2001, he joined the art staff of the magazine 'W.i.t.c.h.', for which he has illustrated stories and covers. Bertolucci also also contributed covers and illustrations to 'Monster Allergy', as well as a series of short stories with 'The Flintstones' in Il Sole 24 Ore and the coloring for the comic adaptation of Disney's 'Lilo & Stitch'.
He has cooperated with the French scriptwriter Frédéric Brrémaud on 'Richard Coeur De Lion' (Soleil, 2005-2007), 'Les Tennismen' (Bamboo, 2006), 'Rocambole de Ponson du Terrail' (Delcourt, 2009) and 'Love' (Ankama Éditions, 2011-2012).