Emanuele Taglietti was born in 1943 in Ferrara, of the region of Emilia-Romagna, Italy. His father, Otello, was a painter and a decorator. In the 1960s, Otello Taglietti worked as a set designer on movies made by his cousin, acclaimed director Michelangelo Antonioni, often taking Emanuele with him on the set.
After attending a local art school, Emanuele Taglietti studied design at the Experimental Centre of Cinematography, in Rome. He worked as a decorator and an assistant director for around thirty movies, including Federico Fellini's Juliet of the Spirits, Dino Risi's Dirty Weekend, and others.
By the early 1970s, the popularity in Italy of the digest-sized fumetti comics, whose themes were mostly sex, violence, and horror, was at its peak. Taglietti moved on to work as an illustrator for Edifumetto, the biggest publisher of fumetti in Italy.
At the time, Taglietti would often paint more than ten covers every month for Renzo Barbieri's publishing house. By the end of the 1980s, the comics' popularity started to weaken, and Taglietti left Edifumetto to work as an oil painter, as well as an evening-class teacher in decoration and the conservation of murals. In 2000, he retired from teaching, continuing to work as murals and watercolor painter.