Born on Sardinia, Antonio Cossu eventually settled in Brussels, Belgium. While studying at the Institut Saint-Luc in Brussels, he published his first work in magazines like Curiosity Magazine and Spatial. At the Saint-Luc's Atelier R, he cooperated on the third edition of Le Neuvième Rêve, for which he created a first version of 'Boskovich'. After a brief appearance in Aïe!, he made his debut in Spirou with the series 'Alceister Crowley' in 1980.
He drew his first album for Deligne ('Sang Anesthésié), while also creating several short stories for Le Journal Illustré, Métal Hurlant, Tintin and Pilote. Several of these short stories were collected in the album 'No Man's Land', at Les Humanoïdes Associés in 1984.