Antonio Canale was born in Monza, in the district of Milan. Canale started to draw comics very early, as Nino Pagot's assistant. He did his first works for Il Cartoccino and Il Corriere dei Piccoli, and drew his first comic, 'Piuma Verde' for Il Vittorioso in 1937. The script was by Gianluigi Bonelli, with whom Canale also made 'Sigrido' in L'Audace. In 1939, he illustrated 'Il Solitario dei Sakya' with a script by Federico Pedrocchi in Topolino. After his military service, he returned to Il Vittorioso, where he drew among others 'Valore Italico'. In 1943, he succceed Raffaele Paparella as the artist of 'Cabiria' in Topolino, and two years later, he illustrated 'I Dominatori dell'Abisso', another story scripted by Bonelli.