After obtaining his degree in geometry, Andrea Mutti attended the Comics School in Brescia, led by Ruben Sosa. He began his career illustrating the superheroes comic 'DNAction' for Xenia Edizioni. He then illustrated horror comics for Fenix. He moved over to Star Comics, where he drew stories with 'Lazarus Ledd' and some episodes of 'Hammer'. Between 1993 and 2000, he was one of the artists for the Bonelli series 'Nathan Never'.